Zinc aspartate induces proliferation of resting and antigen-stimulated human PBMC under high-density cell culture conditionArticle Published on 2023-05-012023-06-24 Journal: Journal of trace elements in medicine and biology [Category] 신종인플루엔자, [키워드] Apoptosis cytokine production PBMC proliferation Zinc aspartate. [DOI] 10.1016/j.jtemb.2023.127152 PMC 바로가기
The presence of SARS-CoV-2 in multiple clinical specimens of a fatal case of COVID-19: a case reportCase Reports Published on 2022-12-222023-07-11 Journal: Journal of Medical Case Reports [Category] COVID19(2023년), [키워드] COVID-19 lymphoma PBMC SARS-CoV-2 severe disease viremia. [DOI] 10.1186/s13256-022-03706-y PMC 바로가기 [Article Type] Case Reports
Epigenetic rewiring of pathways related to odour perception in immune cells exposed to SARS-CoV-2 in vivo and in vitroArticle Published on 2022-12-012023-07-09 Journal: Epigenetics [Category] COVID19(2023년), [키워드] DNA methylation in vitro stimulation interactome Mild-to-moderate module identification network analysis. PBMC SARS-CoV-2 [DOI] 10.1080/15592294.2022.2089471 PMC 바로가기
Single-cell transcriptomic atlas reveals distinct immunological responses between COVID-19 vaccine and natural SARS-CoV-2 infectionArticle Published on 2022-11-012022-11-15 Journal: Journal of medical virology [Category] COVID19(2023년), SARS, 유전자 메커니즘, 진단, [키워드] Activation acute respiratory syndrome alteration analysis antibody production Apoptosis B cell caused collected CoronaVac coronavirus COVID-19 COVID-19 infected patient COVID-19 patients COVID-19 vaccine cytotoxicity downregulation Emergency use authorization expression expression of gene feature greater HLA class II IL21R immune Immune cell immune cell types immune response immunization immunized immunological Immunological response immunological responses inactivated Inactivated vaccine individual individuals Infection Inflammatory cytokine innate immune cell interferon response magnitude mechanism Migration mononuclear cells naïve B cell naïve B cells pandemic PBMC Peripheral blood phenotype plasma profile Proinflammatory cytokine proportion provide reveal SARS-CoV-2 SARS-COV-2 infection scRNA-seq Sequencing severe disease single-cell Single-cell RNA sequencing single-cell sequencing. Sinovac systemic immune response T cell thrombosis transcriptomic upregulation vaccine-induced immune response [DOI] 10.1002/jmv.28012 PMC 바로가기
Identification of TCR repertoires in asymptomatic COVID-19 patients by single-cell T-cell receptor sequencingResearch article Published on 2022-11-012022-10-05 Journal: Blood cells, molecules & diseases [Category] COVID19(2023년), SARS, 변종, [키워드] analyzed Asymptomatic Asymptomatic COVID-19 asymptomatic infection cell-mediated immune response Combination COVID-19 COVID-19 patient dominant effective FIVE healthy control help identification identify Immunity Immunopathogenesis Immunotherapy J gene Patient PBMC performed SARS-CoV-2 SARS-COV-2 infection scTCR-seq Sequencing single-cell skewed study groups subjects symptomatic T cell response T-cell receptor TCR TCR repertoires TCR sequencing therapeutic strategy viral infection [DOI] 10.1016/j.bcmd.2022.102678 [Article Type] Research article
The Peripheral Immune Landscape in a Patient with Myocarditis after the Administration of BNT162b2 mRNA VaccineArticle Published on 2022-10-312022-11-15 Journal: Molecules and cells [Category] COVID19(2023년), SARS, 진단, 치료기술, [키워드] acute respiratory syndrome analysis approved BNT162b2 BNT162b2 mRNA vaccination causes cell clusters change changes in complications coronavirus Differentially expressed genes global public health help IL7R immune increased expression increased risk landscape Messenger RNA monocyte mononuclear cell mRNA myocarditis of BNT162b2 pandemic Pathogenesis Patient PBMC PBMCs peripheral Peripheral blood peripheral blood mononucleear cells reported Research SARS-CoV-2 Sequencing severe acute respiratory syndrome coronavirus 2 single-cell Single-cell RNA sequencing single-cell RNA sequencing. T cell receptor Transcriptome transcriptomic profile vaccinated individual vaccination Vaccine [DOI] 10.14348/molcells.2022.0031 PMC 바로가기
Vitamin D enhances type I IFN signaling in COVID-19 patientsArticle Published on 2022-10-222022-11-15 Journal: Scientific Reports [Category] COVID19(2023년), SARS, 치료제, [키워드] 95% confidence interval adjusted hazard ratio Admission all-cause mortality antimicrobial peptide Antiviral Antiviral effect antiviral response collected COVID-19 infection COVID-19 patient ENhance Host host response IFN in vitro intensive care interferon investigated ISGs JAK-STAT signaling pathway lower risk modulate on type outcome patient survival patients PBMC protein level Regulatory saliva specimen SARS-CoV-2 SARS-COV-2 infection severe COVID-19 patient Signaling significantly higher treated treated patient treated patients Treatment Type I IFN untreated patient Vitamin D Whole blood [DOI] 10.1038/s41598-022-22307-9 PMC 바로가기
Reconstructed Genome-Scale Metabolic Model Characterizes Adaptive Metabolic Flux Changes in Peripheral Blood Mononuclear Cells in Severe COVID-19 PatientsArticle Published on 2022-10-172022-11-15 Journal: International Journal of Molecular Sciences [Category] COVID19(2023년), SARS, 유전자 메커니즘, 치료제, [키워드] acute respiratory syndrome adaptive aerobic Analysis anti-inflammatory effect antiviral drugs biogenesis caused change changes in Coronavirus disease 2019 Coronavirus-2 COVID-19 differentially expressed enzyme FASN fatty flux Glycolysis Health Immune cell Inflammation Inflammatory lipids mechanism metabolic metabolic model metabolism metabolism-directed therapy. metabolites Model mononuclear cell nucleotide oxidative phosphorylation pathogenic PBMC PBMCs peripheral Peripheral blood potential therapeutic targets provide reaction reconstructed Regulation responsible retinol SARS-CoV-2 severe COVID-19 patients SLC2A3 therapy Transcriptome Treatment Vitamin [DOI] 10.3390/ijms232012400 PMC 바로가기
Upregulation of hsa_circ_0004812 promotes COVID-19 cytokine storm via hsa-miR-1287-5p/IL6R, RIG-I axisArticle Published on 2022-10-012022-11-16 Journal: Journal of Clinical Laboratory Analysis [Category] COVID19(2023년), SARS, 유전자 메커니즘, [키워드] Asymptomatic bioinformatics Bioinformatics analysis cDNA synthesis competing contagious correlation Correlation analysis CoV COVID-19 COVID-19 cytokine storm cytokine Cytokine storm expressed expression expression level expressions healthy controls hsa_circ_0004812 hsa-miR-1287-5p IL-6R IL6R in silico In-vitro Interaction material molecular mechanisms mononuclear cell negative control outcome pandemic Patient patients patients with asymptomatic PBMC Peripheral blood positive correlation positively correlated predicted promote qRT-PCR relative expression RIG-I RNA SARS-CoV-2 sponging effect. Symptom symptomatic the Coronaviridae the SARS-CoV-2 total RNA virus was performed [DOI] 10.1002/jcla.24666 PMC 바로가기
Vitamin D modulates systemic inflammation in patients with severe COVID-19Research article Published on 2022-10-012022-10-05 Journal: Life sciences [Category] 바이오마커, 임상, 치료기술, [키워드] AKT Anti-inflammatory effects attenuate Blood blood sample C-reactive protein clinical setting condition COVID-19 COVID-19 infection D-dimer ELISA evaluate expression Hyperinflammatory ICU IL-17 IL-1β IL-6 immune response immunomodulatory in vitro Inflammatory response intensive care investigated JNK marker material modulate Nasopharyngeal swab pathway Patient patients PBMC Proinflammatory cytokine reveal Serum level severe COVID-19 severity signaling pathway Significance STAT3 stimulated systemic inflammation treated treated patient Treatment untreated patient Vitamin D was used western blotting with COVID-19 [DOI] 10.1016/j.lfs.2022.120909 [Article Type] Research article